Small Molecule Induced Conversion of Toxic Oligomers to Non-Toxic Beta-Sheet-Rich Amyloid Fibrils
نویسندگان
چکیده
منابع مشابه
Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils.
Several lines of evidence indicate that prefibrillar assemblies of amyloid-β (Aβ) polypeptides, such as soluble oligomers or protofibrils, rather than mature, end-stage amyloid fibrils cause neuronal dysfunction and memory impairment in Alzheimer's disease. These findings suggest that reducing the prevalence of transient intermediates by small molecule-mediated stimulation of amyloid polymeriza...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.11.2494